International Review of Ophthalmology ›› 2022, Vol. 46 ›› Issue (2): 157-161.doi: 10.3760/ cma.j.issn.1673-5803.2022.02.011

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MicroRNA and their regulating effects in lacrimal gland adenoid cystic carcinoma

Shao Yaqi, Ma Jianmin   

  1. Beijing  Key Laboratory of Ophthalmology and Visual Science; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
  • Received:2021-04-19 Online:2022-04-22 Published:2022-04-24
  • Contact: Ma Jiamin, Email:jmma@sina.com
  • Supported by:
    Beijing Natural Science Foundation (7222025); Special Fund for "Peak Climbing" Plan of Beijing Hospital Management Center (DFL20190201)　　

Abstract: Lacrimal gland adenoid cystic carcinoma(LGACC) is a common malignant epithelial tumor of  lacrimal gland, which has high recurrence rate and metastasis rate. In recent years, it has been found that a variety of microRNAs play an important role in the occurrence and development of LGACC. Overexpression of miR-24-3p can promote the expression of p53 / p21 by reducing the expression of PRKCH in LGACC, so as to inhibit tumor invasion. MiR-93-5p regulates Wnt signaling pathway and down regulates breast cancer metastasis suppressor 1 (BRMS1) L, and promotes epithelial mesenchymal transition (EMT), migration, invasion and proliferation of LGACC cells. The up-regulated expression of miR-181a-5p in LGACC is also one of the reasons for the proliferation and migration of LGACC cells. (Int Rev Ophthalmol, 2022, 46:  157-161)


Key words: lacrimal gland adenoid cystic carcinoma, microRNA